After 1 day
-0.56%$104.94 → $104.35
Aug 04, 2026 → Aug 05, 2026
Spyre Therapeutics, Inc. Common Stock
/ SYRENMSWhat is SYRE stock?
SYRE is the U.S. stock ticker for Spyre Therapeutics, Inc. Common Stock.
As of 2026-10-29: price $99.75; market cap $9.26B; latest earnings 2026-08-04; 12 recent 13F changes.
$99.75+0.71%
Yahoo Finance ↗·Updated 10/29/2026, 06:46 AM UTC
- Current price
- $99.75
- Market cap
- $9.26B
- Latest earnings date
- Aug 04, 2026
- Data status
- Current
Yahoo Finance
Polygon.io
Nasdaq
Price change after earnings
After 7 days
-2.10%$104.94 → $102.74
Aug 04, 2026 → Aug 11, 2026
After 30 days
-16.86%$104.94 → $87.25
Aug 04, 2026 → Sep 03, 2026
Before-market or after-market timing is unavailable.
Reported date confirmed
Recent insider transactions
| Date | Trader / role | Type | Shares | Average price | Transaction value | Source |
|---|---|---|---|---|---|---|
| Oct 01, 2026 | Burrows Scott L Chief Financial Officer | Sold | 600 | $89.07 | $53.44K | SEC ↗ |
| Oct 01, 2026 | Burrows Scott L Chief Financial Officer | Sold | 1,500 | $90.27 | $135.41K | SEC ↗ |
| Oct 01, 2026 | Burrows Scott L Chief Financial Officer | Sold | 2,100 | $91.92 | $193.03K | SEC ↗ |
| Oct 01, 2026 | Burrows Scott L Chief Financial Officer | Sold | 3,071 | $92.95 | $285.45K | SEC ↗ |
| Oct 01, 2026 | Burrows Scott L Chief Financial Officer | Sold | 229 | $93.57 | $21.43K | SEC ↗ |
| Oct 01, 2026 | Turtle Cameron director · Chief Executive Officer | Sold | 600 | $89.14 | $53.48K | SEC ↗ |
| Oct 01, 2026 | Turtle Cameron director · Chief Executive Officer | Sold | 2,683 | $90.10 | $241.74K | SEC ↗ |
| Oct 01, 2026 | Turtle Cameron director · Chief Executive Officer | Sold | 2,638 | $91.49 | $241.35K | SEC ↗ |
| Oct 01, 2026 | Turtle Cameron director · Chief Executive Officer | Sold | 3,989 | $92.31 | $368.22K | SEC ↗ |
| Oct 01, 2026 | Turtle Cameron director · Chief Executive Officer | Sold | 4,990 | $93.37 | $465.92K | SEC ↗ |
| Oct 01, 2026 | Turtle Cameron director · Chief Executive Officer | Sold | 100 | $93.91 | $9.39K | SEC ↗ |
| Oct 01, 2026 | King-Jones Heidy See Remarks | Sold | 400 | $89.24 | $35.7K | SEC ↗ |
Burrows Scott LSold
Chief Financial Officer
600 · $89.07 · $53.44K
Oct 01, 2026SEC Form 4 ↗
Burrows Scott LSold
Chief Financial Officer
1,500 · $90.27 · $135.41K
Oct 01, 2026SEC Form 4 ↗
Burrows Scott LSold
Chief Financial Officer
2,100 · $91.92 · $193.03K
Oct 01, 2026SEC Form 4 ↗
Burrows Scott LSold
Chief Financial Officer
3,071 · $92.95 · $285.45K
Oct 01, 2026SEC Form 4 ↗
Burrows Scott LSold
Chief Financial Officer
229 · $93.57 · $21.43K
Oct 01, 2026SEC Form 4 ↗
Turtle CameronSold
director · Chief Executive Officer
600 · $89.14 · $53.48K
Oct 01, 2026SEC Form 4 ↗
Turtle CameronSold
director · Chief Executive Officer
2,683 · $90.10 · $241.74K
Oct 01, 2026SEC Form 4 ↗
Turtle CameronSold
director · Chief Executive Officer
2,638 · $91.49 · $241.35K
Oct 01, 2026SEC Form 4 ↗
Turtle CameronSold
director · Chief Executive Officer
3,989 · $92.31 · $368.22K
Oct 01, 2026SEC Form 4 ↗
Turtle CameronSold
director · Chief Executive Officer
4,990 · $93.37 · $465.92K
Oct 01, 2026SEC Form 4 ↗
Turtle CameronSold
director · Chief Executive Officer
100 · $93.91 · $9.39K
Oct 01, 2026SEC Form 4 ↗
King-Jones HeidySold
See Remarks
400 · $89.24 · $35.7K
Oct 01, 2026SEC Form 4 ↗
Updated: 10/03/2026, 03:35 PM UTC
13F institutional changes
| Quarter | Institution | Type | Shares held | Share change | Value change | Source |
|---|---|---|---|---|---|---|
| Jun 30, 2026 | FMR LLC / Fidelity | Added | 13,026,187 | +1,245,163 | +$562.23M | SEC 13F ↗ |
| Jun 30, 2026 | BlackRock, Inc. | Added | 6,506,605 | +985,384 | +$299.17M | SEC 13F ↗ |
| Jun 30, 2026 | Vanguard Capital Management LLC | Added | 3,448,681 | +391,280 | +$151.96M | SEC 13F ↗ |
| Jun 30, 2026 | State Street Corp | Added | 3,057,416 | +450,385 | +$139.94M | SEC 13F ↗ |
| Jun 30, 2026 | Geode Capital Management, LLC | Added | 2,562,265 | +841,353 | +$152.44M | SEC 13F ↗ |
| Jun 30, 2026 | Vanguard Portfolio Management LLC | Added | 2,330,098 | +1,744,968 | +$177.35M | SEC 13F ↗ |
| Mar 31, 2026 | Perceptive Advisors LLC | Unchanged | 3,783,225 | — | — | SEC 13F ↗ |
| Jun 30, 2026 | JPMorgan Chase & Co. | New position | 1,093,026 | +113,727 | +$54.39M | SEC 13F ↗ |
| Mar 31, 2026 | Wellington Management Group LLP | Added | 1,824,811 | +275,735 | +$13.91M | SEC 13F ↗ |
| Mar 31, 2026 | Capital International Investors | Reduced | 1,746,129 | -1,746,129 | -$88.07M | SEC 13F ↗ |
| Mar 31, 2026 | Janus Henderson Group PLC | Unchanged | 1,656,164 | — | — | SEC 13F ↗ |
| Mar 31, 2026 | Bank of America Corp. | Added | 1,228,093 | +808,376 | +$40.77M | SEC 13F ↗ |
FMR LLC / FidelityAdded
- Quarter
- Jun 30, 2026
- Shares held
- 13,026,187
- Share change
- +1,245,163
- Value change
- +$562.23M
BlackRock, Inc.Added
- Quarter
- Jun 30, 2026
- Shares held
- 6,506,605
- Share change
- +985,384
- Value change
- +$299.17M
- Quarter
- Jun 30, 2026
- Shares held
- 3,448,681
- Share change
- +391,280
- Value change
- +$151.96M
State Street CorpAdded
- Quarter
- Jun 30, 2026
- Shares held
- 3,057,416
- Share change
- +450,385
- Value change
- +$139.94M
- Quarter
- Jun 30, 2026
- Shares held
- 2,562,265
- Share change
- +841,353
- Value change
- +$152.44M
- Quarter
- Jun 30, 2026
- Shares held
- 2,330,098
- Share change
- +1,744,968
- Value change
- +$177.35M
Perceptive Advisors LLCUnchanged
- Quarter
- Mar 31, 2026
- Shares held
- 3,783,225
- Share change
- —
- Value change
- —
JPMorgan Chase & Co.New position
- Quarter
- Jun 30, 2026
- Shares held
- 1,093,026
- Share change
- +113,727
- Value change
- +$54.39M
- Quarter
- Mar 31, 2026
- Shares held
- 1,824,811
- Share change
- +275,735
- Value change
- +$13.91M
- Quarter
- Mar 31, 2026
- Shares held
- 1,746,129
- Share change
- -1,746,129
- Value change
- -$88.07M
Janus Henderson Group PLCUnchanged
- Quarter
- Mar 31, 2026
- Shares held
- 1,656,164
- Share change
- —
- Value change
- —
- Quarter
- Mar 31, 2026
- Shares held
- 1,228,093
- Share change
- +808,376
- Value change
- +$40.77M
Share counts are derived from reported value divided by the filing price and are rounded for display.
Key people timeline
Unavailable
Related data
Data sources and methodology
Prices use Yahoo Finance, earnings dates use Nasdaq, and company reference data prefers Polygon.io. When Polygon market cap is unavailable, the page derives it from the latest SEC shares outstanding multiplied by the Yahoo price. Insider and institutional records link to SEC EDGAR, and missing values are never invented.
Updated: 10/29/2026, 06:46 AM UTC
Collection, calculation and correction policy- Yahoo Finance
- 10/29/2026, 06:46 AM UTC
- Polygon.io
- 10/29/2026, 06:46 AM UTC
- Nasdaq earnings history
- 08/04/2026, 12:00 AM UTC
- SEC Form 4
- 10/03/2026, 03:35 PM UTC
- SEC 13F
- 08/13/2026, 06:05 PM UTC
- Statements / public records
- Unavailable